Jacobus – OSD Manufacturing Facility
Cyma Builders & Construction Managers have been retained by Jacobus Pharmaceuticals, Inc. to provide Pre-Construction, Construction, and Post-Construction services for their Oral Solid Dosage production facility upgrades in Plainsboro, NJ. The overall facility upgrade program includes complete renovation of (2) existing drug production processes from raw material entry and bulk API generation through final tableting and coating. In addition, several of the overall facility support functions will be renovated and expanded to support expanded capacity and improved circulation, as well as replacement and upgrade of existing building infrastructure. The facility is to remain operational throughout construction, including manufacturing areas, requiring a strategically planned approach to phasing to minimize operational shutdowns.
Construction scope includes renovation and expansion of existing API generation, processing, and tableting suites to improve manufacturing efficiency and production environment quality. Non-GMP and cGMP corridors and air locks will be modified to allow for better facility circulation. New non-GMP and GMP staging areas will be created. Replacement and upgrades of HVAC, Electrical, and non-process utility systems will be completed as necessary to support the renovations. Upgrades to process utility systems and controls will be completed to support the new manufacturing equipment. A central cold storage box will be installed to support all OSD functions. A new receiving dock will be constructed for receipt of raw materials, along with a new hazardous material storage containment area. Removal and modifications of existing process equipment to improve efficiency in loading and transfer of materials. Installation of new process equipment will includes Reactors, Centrifuges, Charcoal Settlers, Dryers, Presses, Coaters, Mixers and Misc. Production and Packaging Equipment. Final installation of interconnecting process utilities and controls for material transfer will complete the project.