Author Archive

Cyma Builders Breaks Ground on Phase 2 of August Bioservices Expansion

Phase 2 Expansion has commenced and is off to an explosive start, both literally and figuratively! Breaking ground on this expansion took on a whole new meaning when the project team utilized explosives to blast through the existing bedrock.

All this effort will eventually lead to the foundation that will house a new aseptic manufacturing facility with the capacity to double their fill/finish capabilities. 

Stay tuned for more exciting updates!

Cyma Builders Completes Phase 1 of August Bioservices Expansion

Cyma Builders is proud to announce it successfully completely the first of two (2) manufacturing expansion projects of August Bioservices Nashville manufacturing operations. The first expansion focused on renovating August Bio’s existing facility to increase manufacturing capacity and development capabilities for liquid and lyophilized vial filling, prefilled syringe fillin, IV bags and terminal sterilization.

Together, August Bioservices & Cyma Builders are growing pharmaceutical manufacturing in Nashville, Tennessee! 

Watch the video showcasing August Bioservices manufacturing expansion here!

Confidential – CAR-T R&D Laboratory

Cyma Builders and Construction Managers was retained by a confidential client to construct a new 12,000 SF R&D laboratory. The lab was designed to be in compliance with current BSL 2 and BSL 2+ biosafety levels to support current and future cell therapy initiatives.

              As a part of the overall project, the team was tasked with demolishing an existing production space. This production space was mothballed in the early 2000’s and had not been used since. The demolition included the removal of full height (28’+) CMU partitions that were adjacent to active operations at the facility as well as the existing slab and production mezzanine. After coordinating with the facility, Cyma was able to develop a strategy that allow these areas to stay in operation during the demolition phase while still ensuring the work could proceed on schedule. This was done by transferring the heavy demolition to nights while ensuring that all active areas were vacated before the night shift started. As the demolition progressed, it was discovered that many critical utilities to the facility had been installed in the space since it had been decommissioned. Almost all of these utilities were undocumented and required an extensive survey by the construction team to identify. Cyma was able to perform this survey and coordinate shutdowns to relocate the utilities with minimal impact to the overall project schedule.

                After the existing utility issue was addressed, it was discovered that there were a number of existing conditions in the field that would cause a number of structural concerns if the demolition was carried out as per the drawings. Specifically, the existing production mezzanine that was being demolished was actually integral to a large, freestanding CMU wall that was not scheduled to be demolished. The structural elements that were being demolished were part of the structure needed to keep this wall in place. The construction team quickly identified this issue and, with design team assistance, was able to modify the demolition plan to allow part of this mezzanine to remain in place. This change allowed the wall to remain which allowed a critical active area at the facility to remain in service.

                Once the demolition was completed, Cyma proceeded to the underground phase of the project. The underground phase involved the installation of new footings, infill of an existing MEP courtyard to bring it up to the finished floor elevation, and the installation of new underground process waste drainage system. The installation of the footings required two substantial excavations to get to the depth required, which was achieved safely and without incident. The new underground process waste drainage consisted of new Asahi double wall piping for all of the new work, and the installation of an FRP reinforced cure in place (CIP) epoxy liner for all existing piping. The pipe lining installation was an extremely difficult task that required surgical, deep excavations in the existing building and outside of the main lobby to perform properly. Unfortunately, it was discovered during the installation that the as-builts that were made available to the project were very inaccurate and not representative of the actual existing pipe routing. Cyma was able to work with their subcontractor to provide alternate options to allow the work to continue despite these hurdles.  

                After the pipe lining was completed and the new piping was integrated into the process waste system, Cyma proceeded to the structural phase of the project. This involved the construction of a new steel frame to support a new second floor shell space that was being provided as part of the project. The purpose of the shell space was to support a future office fit out and provide mechanical & electrical support spaces for the main project. The structural phase was completed without incident and on schedule, and involved the use of a spyder crane so the structure could be erected safely within the existing building envelope. Once the structure was completed, Cyma proceed to install a new concrete slab on the ground floor as well as on the new second floor. Due to the square footage of floor being installed, the concrete subcontractors advised that they would have to use gas powered equipment indoors during the concrete pour. After coordinating with the subcontractor, Cyma deployed an extensive exhaust system consisting of over 28 exhaust fans to ensure that the exhaust fumes were quickly removed from the space and did not migrate to other areas of the plant. The team actively monitored carbon monoxide inside and outside of the work areas throughout both concrete pours to confirm the solution deployed was having the desired effect.

                Now that the structure was complete, the team moved into the fit out phase of the project. The BSL2+ portion of the new labs included a new drywall ceiling as part of it’s final finishes. The client also advised that they wanted to minimize or eliminate the use of any access panels in this space due to concerns with containment in the lab during normal operations. Prior to the fit out phase, Cyma coordinated directly with each subcontractor to ensure that everyone was aware of  the constraints with working in the space so they would be properly prepared when the work began. The contractor’s shop drawings were designed in such a way that minimized conflicts between trades in the field and also kept critical devices close to MEP penetrations so access panels would not be necessary. Using this strategy, Cyma was able to complete the fit out in the BSL2+ area without the use of a single access panel. The BSL2 fit out was also coordinated in this manner, however it was much easier to execute since it was in a ACT ceiling.

                As the fit out progressed, the client advised that there was significant shortage of both electrical and tele data services to all equipment spaces throughout the space. This issue was discovered approximately four weeks before turnover and involved a significant rework throughout the space. Unfortunately, the rework involved was very extensive and could not be fully completed before the original turnover date. Once the problem was identified, Cyma proceeded to coordinate with it’s subcontractors to identify the critical areas that needed to be completed by the original date. Cyma successfully deployed the changes in these areas while simultaneously ensuring that work was also proceeding in the other areas. The result is that the client was able to open lab on schedule, and the remaining changes were completed approximately two weeks after the original completion date.

                There was a significant amount of new infrastructure that was installed as part of the overall project. The new HVAC equipment included the installation of a new 27,000 CFM AHU, seven exhaust fans, a Bag in / Bag Out filter housing for the exhaust stream from the labs, and a number of automated dampers and other control items. The mechanical equipment installed includes a new DI system, HVAC chiller and pumps to backup critical loads, and new gas manifolds for the new CO2 and O2 gas distribution. The electrical infrastructure included a new UPS and ATS to support the new critical lab equipment being installed throughout the space.

                It is also important to note that there were a large number of utility shutdowns throughout the project to allow for new mechanical, electrical, and plumbing utilities to be demolished or installed. Cyma was responsible for coordinating each one of these shutdowns with the owner, end users, as well as the facility’s maintenance group. All shutdowns proceeded in a controlled manner and without incident, and Cyma is happy to report that there was no unexpected shutdowns or production / research interruptions throughout the project.  

Cyma Creates Successful Safety Culture at Janssen PDMS Project

Cyma Builders & Construction Managers Creates Successful Safety Culture at Janssen PDMS Expansion Project

Cyma Builders and Construction Managers, in conjunction with our contractors and Janssen Pharmaceutical LLC, successfully created and fostered a proactive, effective and collaborative safety culture on this fast track project.

Janssen Pharmaceutical Research & Development LLC based in Malvern PA selected Cyma Builders to expand their footprint to an existing multi-tenant facility in Charlestown Township. Multiple tenant spaces were combined to create a new, state of the art, 56,000 square foot Lab and Office Facility. Infrastructure upgrades included installing 4 new air handling units (8,000 CFM each) on 4 individual steel dunnage platforms that are free standing along the rear of the facility, duct work distribution to the research labs, refurbishment of over 15 existing roof top units for the office areas, new and upgraded electrical services from PECO and the installation of two emergency generators.

New laboratory services include upgraded glass-wash and sterilization equipment, two cold boxes, new purified water system, compressed air, nitrogen, CO2, vacuum and oxygen distribution systems. Existing lab casework was supplemented with new lab casework and components to suit the end user requirements. New finishes included epoxy flooring, clean room ceiling and epoxy paint.

The project was fully Commissioned and met LEED requirements for Certified status, and the Certificate of Occupancy was issued in mid-May 2018.

From the pre-construction planning stage to project completion, the client and construction team all displayed a genuine commitment to supporting and prioritizing worker safety on the project. The construction team created a hands-on approach to safety that allowed all personnel on the project to become safety advocates, not only being safe themselves but looking out for the safety of others. As the safety culture grew, organizational barriers such as fear and lack of trust in safety, were diminished. Contractors started thinking safety, reviewing their own JSA’s weekly, consulting with the onsite Safety Specialists for ways to conduct tasks safely as they reacted to unforeseen conditions in the field.

The emphasis on worker safety and the establishment of an effective safety culture led to the project far exceeding safety metric goals with over 70,000 hours worked with no Recordable Injuries or Lost Work Time Injuries.



‘Safety Culture’ consists of shared beliefs, practices, and attitudes that exist at an establishment or on a project. Culture is the atmosphere created by those beliefs, attitudes, etc., which shape our behavior.

By project completion, the safety effort on the PDMS Expansion Project was an excellent example of an effective Safety Culture.



Safety Jeopardy Created by Mike Royce, Sr. for the PDMS Expansion Project and hoisted at weekly safety luncheons; this safety game consisted of 3 contestants chosen at random from the contractors onsite competing for prizes by answering construction safety questions. Safety Jeopardy questions were selected based on the topic of the toolbox talk presented at the safety luncheon to reinforce the message of the toolbox talk.  Contractors took an interest in knowing the topics and, even when not chosen, enjoyed competing and knowing the answers.

Safety Jeopardy and a Safety Luncheon

Weekly JSA Reviews – A project specific Cyma Builders commitment included requiring contractors to conduct weekly JSA reviews and understand, discuss and reinforce Cyma and Janssen safety policies along with any changes or hazards encountered that were not captured in the approved JSAs.

H.B. Frazer conducting a weekly JSA review.

Safety Stand-Downs – Awareness and training sessions intended to help mitigate the impact of hazards in construction. These meetings were held with contractors to discuss safety issues occurring onsite or nationally and also to help inform contractors of recent incidents, near misses, corrective actions, etc. Safety Stand-Downs are intended to interrupt work and focus worker attention on specific safety messages and information.

National Fall Protection Safety Stand Down session held on PDMS project. 

Centralized, Organized and Accessible Safety Documentation – Files kept at the site entrance that are readily available for contractors to review & sign daily, weekly or monthly; centralized organization and availability of safety documentation helped workers to review and understand the safety requirements.


For more information about Cyma Builders & Construction Manager, please visit us at

Safe and Successful Completion of a Critical Steam Shutdown

Cyma Builders & Construction Managers Announces the Safe and Successful Completion of a Critical Steam Shutdown

Cyma Builders and Construction Managers recently managed the successful completion of a critical site wide steam shutdown to replace a main steam distribution header at a large pharmaceutical research and development facility in Montgomery County, PA. This steam shutdown is part of an ongoing $3.6 million-dollar project to replace two existing 500 horsepower BTU boilers inside the Central Utility Plant. The two boilers and the associated steam header provide steam for heating, hot water as well as for critical vivarium and pilot plant operations.

In advance of the steam shutdown, Cyma Builders coordinated all aspects of the outage and worked with the installing Mechanical contractor (Herman Goldner Co., Inc.), site maintenance and engineering, facility personnel and several end users/client groups in order to minimize the impact to site operations.

The steam shutdown started on Friday, September 7, 2018 at 6:00 PM and continued around the clock through Sunday afternoon. The shutdown of the steam supply had to wait for off-peak hours to minimize interruptions to normal daily operations. A temporary boiler was mobilized to the site and piped in to existing steam distribution piping to provide critical steam for the site’s active vivarium.  Herman Goldner Co., Inc. and Vasoli Electric Co., Inc. (Electrical contractor) installed utilities for this temporary boiler ahead of the shutdown.

Herman Goldner Co., Inc. removed the existing header and associated piping then installed the new steam header, steam pipes and hangers while working from aerial lifts, scaffold towers and portable ladders. Significant pre-planning and attention to detail was exercised to prevent welding flash and possible property damage in the confined work area; welding screens and fire blankets were installed throughout the work site.

With excellent pre-planning and coordination of contractors and site personnel, this steam shutdown was completed safely, on time and with minimal interruption to site operations.

For  more  information  about  Cyma  Builders  &  Construction  Managers,  please  visit

Confidential – CAR-T Cell Therapy Lab

Cyma Builders and Construction Managers was retained by a confidential client to construct a new pilot plant at their existing PA facility. This pilot plant was designed to support a new cell therapy suite that was being designed and constructed at another facility. Due to the role of this new suite, it was imperative that it be completed and put into operation before the other facility was constructed.

The overall project consisted of the demolition of an existing suite that was renovated to accommodate the new program. The new suite included some new mechanical infrastructure while also re-purposing and modifying two existing packaged AHU’s that were used for the previous suite. The overall finishes installed in the suite included epoxy paint throughout, as well as a troweled epoxy floor. Cyma was also responsible for installing a number of bio safety cabinets and clean room pass thru’s as part of the project.

The original project schedule showed the suite being completed in early June of 2018, and was contingent on receiving funding for the project in November of 2017. Unfortunately, funding was not released for the project until late January of 2018. Due to the criticality of the suite to future operations, the client insisted that the early June completion date be maintained as much as possible. Once released, Cyma Builders worked extensively with the design engineers and vendors to identify the long lead components on the critical path. Once identified, a methodical approach was taken to try to ensure that the long lead components were onsite when needed to achieve the project schedule. Using this strategy, Cyma was able to receive over 95% of the equipment on time, with the remaining 5% not arriving due to manufacturer related shortages.

Once the issue with the long lead equipment was resolved, Cyma began working on constructing the suite. The original construction schedule assumed 20 weeks of construction, but the work now had to be performed in 16 weeks due to constraints caused by the lead times of the materials and lack of funding. Cyma developed and implemented a construction plan to complete the work in the required time frame using a negotiated overtime allowance. The allowance was strictly managed to ensure that the money was being spent efficiently to allow the maximum amount of schedule to be recovered for each dollar spent.

During the project, Cyma was also able to use previous work experience in clean room environments to provide useful suggestions to the client. This included recommendations for clean room phones, various finish details, and materials of construction for the various signage that was installed as part of the project.

Confidential – Compounding & Filling Suite

Cyma Builders and Construction Managers was retained by a confidential client to construct a new manufacturing suite with a corresponding compounding suite at their New Jersey facility. The project was commissioned to fulfill the manufacturing needs of a new client that had recently been entered into a contract to manufacture certain products.

The 8,500 SF clean room was constructed to GMP EU classification and within the footprint of an active cGMP manufacturing facility. At the onset of the project, Cyma had to take extensive precautions to ensure the construction activities would not affect the active pharmaceutical manufacturing operations that were being conducted directly adjacent to the new suite. These precautions included clean room temporary partitions, strategic placement of negative air machines to ensure the control of dust and maintain pressure, as well as a diligent clean up effort to ensure that no dust or construction debris migrated into the plant. Cyma was also directly responsible for the flow of the contractors on site and ensuring they did not deviate from approved egress pathways. The FDA, EU, and the manufacturer’s clients conducted several routine and surprise audits during construction without having a single observation that could be attributed to the construction team.

The overall construction included a modular clean room system for all clean room walls, ceiling and doors. The construction team erected an independent structural steel support frame for the clean room within the existing building’s envelope. This construction strategy allowed the project to maintain the walk-ability of the modular clean room ceiling while not affecting the existing building’s structural integrity.

The project had a significant amount of support infrastructure. This included four custom AHU’s, four new chillers as well as a custom TWFI heat exchanger skid for a TWFI sub-loop that was being installed as part of the project. These systems were also tied in to the existing systems already in service at the plant. The project also included extensive modification to one of the two main WFI loops in the plant in order to reverse the flow of the loop to achieve a final design goal of their existing master plan. Throughout the installation of this infrastructure, Cyma worked with the engineering and production teams at the plant to schedule strategic shutdowns to allow the project to maintain schedule while almost completely negating the impact to production.

The project also required the retrofit of two existing Munter’s AHU’s that previously served the existing suite. The AHU’s were decontaminated, and then a thorough inspection process was performed to identify any potential failing parts for replacement. Cyma proceeded with replacing these parts in order to ensure the AHU’s fulfilled their designed role with minimal problems in the future.

The infrastructure was installed on a new two story rooftop/internal mezzanine platform system that was constructed immediately above the process space. This platform  was independently supported from the existing structure. It is important to note that Cyma also worked with the design team to ensure that this platform was completely walkable and unobstructed by any of the ductwork, piping, or other utilities being installed to support the suite below.

National Safety Stand Down 2018

Collegeville, Pennsylvania – May, 2018

Cyma Builders and Construction Managers, in conjunction with Diamond Tool, hosted a Fall Protection Safety Stand Down during the National Safety Stand Down to Prevent Falls in Construction (May 7-11, 2018; According to the Bureau of Labor Statistics, falls from heights are the leading cause of construction related fatality; 370 construction workers were killed from falls in the United States in 2016. Organizations across the country have developed awareness and training programs to help mitigate the impact of the highest fatal event in construction.

Dan Kane, Director of Safety Services for Diamond Tool, spoke to Cyma Builders’ contractors about the importance of fall protection. Dan has worked with manufacturers of fall protection equipment for decades and has been integral to the development and practical application of some of the industry’s leading fall protection equipment. Contractors in attendance learned in depth about specific OSHA and ANSI standards and how the fall protection equipment industry is constantly developing and refining solutions to fall protection challenges. In addition to the discussion, contractors had the opportunity to handle and inspect a variety of current fall protection equipment offerings in a Diamond Tool provided ‘Show and Tell’ session. Cyma hosted 20 different contractors at the Stand Down; attendees were provided with lunch and were issued a 2018 National Fall Protection Stand Down hard hat sticker.

Jeffry Walters, CYMA Superintendent, Safety Certification Achievements

One of Cyma Builders & Construction Managers’ finest Superintendents, Jeff Walters, successfully passed the Board of Certified Safety Professionals (BCSP) and the Safety Trained Supervisor in Construction (STSC) exam in April 2018. The STSC is a nationally recognized third-party safety certification for those with supervisor responsibilities in construction. In the past twenty years, the responsibilities of safety professionals have expanded. Safety issues have become more complex and today’s safety professionals must be continually better qualified. BCSP credential holders are among the most highly trained, educated, and experienced individuals in the safety field. Currently, the BCSP has only 6,000 individuals who actively hold STSC certification.

Jeff has been a Superintendent with Cyma Builders & Construction Managers for 14 years and a member of the Local 167 Northeast Regional Council of Carpenters for 20 years.

“Over the past 5 years I have had the privilege of working with Jeff Walters and this relationship has been a great learning experience for me. I always thought I understood what a safe job site was and how it was supposed to operate but was I naive. As the level of job site safety has matured as required by JNJ and OSHA; Jeff has lead the charge to be the “change agent”. Jeff is truly changing the industry as subs come and go they take with them a new way to do their task a little safer even as they work in other environments across the region. Jeff is truly proud of the work his team produces but more importantly wants his team to go home in the same shape they came to work in. “
~Dave Cochran, Senior Micro-Region, Janssen FM Manager, NA

“Jeff Walters is the gold standard for large construction safety management. During his management of the J&J PDMS Expansion Project he displayed top notch pro-activity and attention to detail, always staying a step ahead and mitigating potential issues and hazards. He creates a culture of safety that becomes infectious to everyone working on the project. His national recognition as a leader in safety is well deserved.”
~Tommy Byrd, Project Manager, Johnson & Johnson Engineering and Property Services.

Individuals with the STSC help employers implement safety programs at the worker level through supervisory, safety committee or similar safety and health leadership roles. Safety tasks often include monitoring for job hazards, helping ensure regulatory compliance, training employees in safety practices, performing safety documentation tasks, coordinating corrections for identified safety hazards within or among work groups, and communicating with safety specialists or management.

In addition to the STSC achievement, Jeff has also recently become a Certified Rigger and Signal Person (CRS) through a rigorous 40-hour training program and certification exam provided by the United Brotherhood of Carpenters. The CRS program focuses on the knowledge and skills necessary to maintain safe working environments during basic rigging and signaling operations. The CRS designation indicates competence in the following areas:

  • Inspects hardware, slings, and rigging equipment
  • Selects the proper hardware for hoisting operations (e.g., takes into account the effect of friction on synthetic slings or hardware)
  • Accounts for the effect of the configuration on the sling stress
  • Performs proper hardware installation and attachment techniques
  • Communicates movements to crane operator using the appropriate voice or hand signals
  • Takes into account the effect of voice or hand signals on the load and the crane
  • Recognizes hazards (e.g., extreme angles, pinch points, criteria for critical hoist)
  • Adjusts for the gross weight of the load in hoisting operations
  • Determines the load weight and center of gravity of symmetrical loads accurately
  • Takes into account how shifting centers of gravity affect load stability

Becton Dickinson – Lab of the Future (Phase 1)

Cyma Builders completed Phase 1 of a 3 Phase project to expand Becton Dickinson’s business development, sales, and equipment training team areas. Phase 1 was a 16,000 square foot construction of labs as well as preparation for Phase 2 future construction. The new floor plans were designed and constructed to provide the client with laboratories in order to work with their new equipment, train employees on the new pieces of equipment, as well as run tests daily. In order to meet the HVAC requirements for future client needs, Cyma needed to remove an outdated Air Handling Unit and replace it with a new 30,000 CFM Air Handling Unit. Also included in these MEP upgrades were installation of two-100HP VFD’s, Exhaust Fans, twenty Hot Water VAV’s, duct silencers, and a new hot water heater. In addition to the updated MEP system, Cyma updated the work environments to include custom casework with lab sinks, mobile lab tables, audio visual, data, and compressed air. Finishes in general were extremely high end with custom stone tile, custom wood toilet partitions that extended floor to ceiling, porcelain tile accent walls, and stone/granite millwork.

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